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NMR Analysis Demonstrates Immunoglobulin G N-glycans are Accessible and Dynamic

The N-glycan at Asn297 of the Immunoglobulin G Fc fragment modulates cellular responses of the adaptive immune system. However, the underlying mechanism remains undefined as existing structural data suggest the glycan does not directly engage cell surface receptors. Here we characterize the dynamics...

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Hlavní autoři: Barb, Adam W., Prestegard, James H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074608/
https://ncbi.nlm.nih.gov/pubmed/21258329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.511
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