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Restricted motion of the conserved immunoglobulin G1 N-glycan is essential for efficient FcγRIIIa binding

Immunoglobulin G1(IgG1)-based therapies are widespread and many function through interactions with low-affinity Fc γ receptors (FcγR). N-glycosylation of the IgG1 Fc domain is required for FcγR binding, though it is unclear why. Structures of the FcγR:Fc complex fail to explain this because the FcγR...

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Sonraí Bibleagrafaíochta
Main Authors: Subedi, Ganesh P., Hanson, Quinlin M., Barb, Adam W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192013/
https://ncbi.nlm.nih.gov/pubmed/25199692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.08.002
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