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Restricted motion of the conserved immunoglobulin G1 N-glycan is essential for efficient FcγRIIIa binding
Immunoglobulin G1(IgG1)-based therapies are widespread and many function through interactions with low-affinity Fc γ receptors (FcγR). N-glycosylation of the IgG1 Fc domain is required for FcγR binding, though it is unclear why. Structures of the FcγR:Fc complex fail to explain this because the FcγR...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4192013/ https://ncbi.nlm.nih.gov/pubmed/25199692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.08.002 |
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