NMR characterization of Immunoglobulin G Fc glycan motion on enzymatic sialylation

The terminal carbohydrate residues of the N-glycan on the immunoglobulin G (IgG) Fragment crystalizable (Fc) determine whether IgG activates pro- or anti-inflammatory receptors. The IgG Fc alone becomes potently anti-inflammatory upon addition of α2–6 linked N-acetylneuraminic acid residues to the N...

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Bibliographic Details
Main Authors: Barb, Adam W., Meng, Lu, Gao, Zhongwei, Johnson, Roy W., Moremen, Kelley, Prestegard, James H.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447994/
https://ncbi.nlm.nih.gov/pubmed/22574931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300319q
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