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Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities
Mdm4 is a critical inhibitor of the p53 tumor suppressor. Mdm4 null mice die early during embryogenesis due to increased p53 activity. In this study, we explore the role that Mdm4 plays in the intestinal epithelium by crossing mice carrying the Mdm4 floxed allele to mice with the Villin Cre transgen...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041067/ https://ncbi.nlm.nih.gov/pubmed/19371999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.diff.2009.03.001 |
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