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The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival
Mdm2 is the major inhibitor of the p53 tumor suppressor. Loss of Mdm2 in mice or in specific tissues of the mouse always yields p53-dependent lethal phenotypes. However, the role of Mdm2 in tissues with high turnover capacity is unknown. We have engineered mice lacking Mdm2 in the intestinal epithel...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2742618/ https://ncbi.nlm.nih.gov/pubmed/18636077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.109 |
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