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Haploinsufficiency of Mdm2 and Mdm4 in Tumorigenesis and Development
The tumor suppressor p53 is inactivated by multiple mechanisms that include mutations of the p53 gene itself and increased levels of the p53 inhibitors MDM2 and MDM4. Mice lacking Mdm2 or Mdm4 exhibit embryo-lethal phenotypes that are completely rescued by concomitant deletion of p53. Here we show t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1952101/ https://ncbi.nlm.nih.gov/pubmed/17526734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00555-06 |
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