Spontaneous tumorigenesis in mice overexpressing the p53 negative regulator Mdm4

High levels of the critical p53 inhibitor Mdm4 is common in tumors which retain a wild-type p53 allele, suggesting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. To test this hypothesis in vivo, we generated transgenic mice with widespread expression of...

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Bibliographic Details
Main Authors: Xiong, Shunbin, Pant, Vinod, Suh, Young-Ah, Van Pelt, Carolyn S., Wang, Yongxing, Valentin –Vega, Yasmine A., Post, Sean M., Lozano, Guillermina
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940952/
https://ncbi.nlm.nih.gov/pubmed/20736370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1457
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