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Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development
Loss of Mdm2 or Mdm4 leads to embryo lethal phenotypes that are p53-dependent. To determine whether Mdm2 and Mdm4 inhibit p53 function redundantly in a more restricted cell type, conditional alleles were crossed to a neuronal specific Cre transgene to delete Mdm2 and Mdm4 in the CNS. Mice lacking Md...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413885/ https://ncbi.nlm.nih.gov/pubmed/16492743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508500103 |
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