The p53–Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity

The p53–Mdm2 feedback loop is perceived to be critical for regulating stress-induced p53 activity and levels. However, this has never been tested in vivo. Using a genetically engineered mouse with mutated p53 response elements in the Mdm2 P2 promoter, we show that feedback loop-deficient Mdm2(P2/P2)...

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Main Authors: Pant, Vinod, Xiong, Shunbin, Jackson, James G., Post, Sean M., Abbas, Hussein A., Quintás-Cardama, Alfonso, Hamir, Amirali N., Lozano, Guillermina
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2013
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778240/
https://ncbi.nlm.nih.gov/pubmed/23973961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.227249.113
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