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The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumorigenesis

The p53 inhibitor Mdm4 is present at high levels in multiple human cancers. Overexpression of Mdm4 in mice drives spontaneous development of mostly lymphomas and sarcomas. In this study, we explored the ability of Mdm4 to cooperate with other lesions in tumour development. The Mdm4 transgene contrib...

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Publicado en:J Pathol
Autores principales: Xiong, Shunbin, Pant, Vinod, Zhang, Yun, Aryal, Neeraj K, You, M. James, Kusewitt, Donna, Lozano, Guillermina
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315583/
https://ncbi.nlm.nih.gov/pubmed/27925213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4854
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