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The inherent instability of mutant p53 is alleviated by Mdm2 or p16(INK4a) loss
The p53 tumor suppressor is often disrupted in human cancers by the acquisition of missense mutations. We generated mice with a missense mutation at codon 172 that mimics the p53R175H hot spot mutation in human cancer. p53 homozygous mutant mice have unstable mutant p53 in normal cells and stabilize...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2377188/ https://ncbi.nlm.nih.gov/pubmed/18483220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1662908 |
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