Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5 – implications for dementia with Lewy bodies

BACKGROUND: In dementia with Lewy bodies (DLB) abnormal interactions between α-synuclein (α-syn) and beta amyloid (Aβ) result in selective degeneration of neurons in the neocortex, limbic system and striatum. However, factors rendering these neurons selectively vulnerable have not been fully investi...

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Autores principales: Overk, Cassia R, Cartier, Anna, Shaked, Gideon, Rockenstein, Edward, Ubhi, Kiren, Spencer, Brian, Price, Diana L, Patrick, Christina, Desplats, Paula, Masliah, Eliezer
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041038/
https://ncbi.nlm.nih.gov/pubmed/24885390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-18
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