Single-molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells

Enhancer-binding pluripotency regulators (Sox2 and Oct4) play a seminal role in embryonic stem (ES) cell specific gene regulation. Here, we combine in vivo and in vitro single-molecule imaging, transcription factor (TF) mutagenesis and ChIP-exo mapping to determine how TFs dynamically search for and...

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Main Authors: Chen, Jiji, Zhang, Zhengjian, Li, Li, Chen, Bi-Chang, Revyakin, Andrey, Hajj, Bassam, Legant, Wesley, Dahan, Maxime, Lionnet, Timothee, Betzig, Eric, Tjian, Robert, Liu, Zhe
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040518/
https://ncbi.nlm.nih.gov/pubmed/24630727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.062
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