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Modulation of CD14 and TLR4.MD-2 activities by a synthetic lipid A mimetic
Monosaccharide lipid A mimetics composed by a glucosamine core linked to two fatty acid chains and bearing one or two phosphates have been synthesized. While compounds 1 and 2, with one phosphate group, were practically inactive in inhibiting LPS-induced TLR4 signaling and cytokine production in HEK...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040397/ https://ncbi.nlm.nih.gov/pubmed/24339336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201300588 |
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