Modulation of CD14 and TLR4.MD-2 activities by a synthetic lipid A mimetic

Monosaccharide lipid A mimetics composed by a glucosamine core linked to two fatty acid chains and bearing one or two phosphates have been synthesized. While compounds 1 and 2, with one phosphate group, were practically inactive in inhibiting LPS-induced TLR4 signaling and cytokine production in HEK...

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Detalhes bibliográficos
Main Authors: Cighetti, Roberto, Ciaramelli, Carlotta, Sestito, Stefania Enza, Zanoni, Ivan, Kubik, Łukasz, Ardá-Freire, Ana, Calabrese, Valentina, Granucci, Francesca, Jerala, Roman, Martín-Santamaría, Sonsoles, Jiménez-Barbero, Jesus, Peri, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040397/
https://ncbi.nlm.nih.gov/pubmed/24339336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201300588
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