Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties

New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A panel of compounds with two carboxylate groups as phosphates bioisosteres, was synthesized with the same glucosamine-bis-succinyl core linked to different unsaturated and saturated fatty acid chains....

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cochet, Florent, Facchini, Fabio A., Zaffaroni, Lenny, Billod, Jean-Marc, Coelho, Helena, Holgado, Aurora, Braun, Harald, Beyaert, Rudi, Jerala, Roman, Jimenez-Barbero, Jesus, Martin-Santamaria, Sonsoles, Peri, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351529/
https://ncbi.nlm.nih.gov/pubmed/30696900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37421-w
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