Macrophage CGI-58 Deficiency Activates ROS-Inflammasome Pathway to Promote Insulin Resistance in Mice

Overnutrition activates proinflammatory program in macrophages to induce insulin resistance (IR), but its molecular mechanisms remain incompletely understood. Here we show that saturated fatty acid and lipopolysaccharide, two factors implicated in high-fat diet (HFD)-induced IR, suppress macrophage...

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Detalhes bibliográficos
Main Authors: Miao, Hongming, Ou, Juanjuan, Ma, Yinyan, Guo, Feng, Yang, Zhenggang, Wiggins, Melvin D., Liu, Chaohong, Song, Wenxia, Han, Xianlin, Wang, Miao, Cao, Qiang, Chung, Bik-Ho Florence, Yang, Dan, Liang, Houjie, Xue, Bingzhong, Shi, Hang, Gan, Lixia, Yu, Liqing
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040312/
https://ncbi.nlm.nih.gov/pubmed/24703845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.02.047
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