Macrophage CGI-58 Deficiency Activates ROS-Inflammasome Pathway to Promote Insulin Resistance in Mice

Overnutrition activates proinflammatory program in macrophages to induce insulin resistance (IR), but its molecular mechanisms remain incompletely understood. Here we show that saturated fatty acid and lipopolysaccharide, two factors implicated in high-fat diet (HFD)-induced IR, suppress macrophage...

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Autors principals: Miao, Hongming, Ou, Juanjuan, Ma, Yinyan, Guo, Feng, Yang, Zhenggang, Wiggins, Melvin D., Liu, Chaohong, Song, Wenxia, Han, Xianlin, Wang, Miao, Cao, Qiang, Chung, Bik-Ho Florence, Yang, Dan, Liang, Houjie, Xue, Bingzhong, Shi, Hang, Gan, Lixia, Yu, Liqing
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040312/
https://ncbi.nlm.nih.gov/pubmed/24703845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.02.047
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