CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

Mutations of Comparative Gene Identification-58 (CGI-58) in humans cause triglyceride (TG) accumulation in multiple tissues. Mice genetically lacking CGI-58 die shortly after birth due to a skin barrier defect. To study the role of CGI-58 in integrated lipid and energy metabolism, we utilized antise...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Brown, J. Mark, Betters, Jenna L., Lord, Caleb, Ma, Yinyan, Han, Xianlin, Yang, Kui, Alger, Heather M., Melchior, John, Sawyer, Janet, Shah, Ramesh, Wilson, Martha D., Liu, Xiuli, Graham, Mark J., Lee, Richard, Crooke, Rosanne, Shulman, Gerald I., Xue, Bingzhong, Shi, Hang, Yu, Liqing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952571/
https://ncbi.nlm.nih.gov/pubmed/20802159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M010256
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