CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

Mutations of Comparative Gene Identification-58 (CGI-58) in humans cause triglyceride (TG) accumulation in multiple tissues. Mice genetically lacking CGI-58 die shortly after birth due to a skin barrier defect. To study the role of CGI-58 in integrated lipid and energy metabolism, we utilized antise...

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Detalhes bibliográficos
Main Authors: Brown, J. Mark, Betters, Jenna L., Lord, Caleb, Ma, Yinyan, Han, Xianlin, Yang, Kui, Alger, Heather M., Melchior, John, Sawyer, Janet, Shah, Ramesh, Wilson, Martha D., Liu, Xiuli, Graham, Mark J., Lee, Richard, Crooke, Rosanne, Shulman, Gerald I., Xue, Bingzhong, Shi, Hang, Yu, Liqing
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952571/
https://ncbi.nlm.nih.gov/pubmed/20802159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M010256
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