Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

Frequent mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) and the promoter of telomerase reverse transcriptase (TERT) represent two significant discoveries in glioma genomics. Understanding the degree to which these two mutations co-occur or occur exclusively of one another in glioma su...

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Autores principales: Killela, Patrick J., Pirozzi, Christopher J., Healy, Patrick, Reitman, Zachary J., Lipp, Eric, Rasheed, B. Ahmed, Yang, Rui, Diplas, Bill H., Wang, Zhaohui, Greer, Paula K., Zhu, Huishan, Wang, Catherine Y., Carpenter, Austin B., Friedman, Henry, Friedman, Allan H., Keir, Stephen T., He, Jie, He, Yiping, McLendon, Roger E., Herndon II, James E., Yan, Hai, Bigner, Darell D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039228/
https://ncbi.nlm.nih.gov/pubmed/24722048
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