Itraconazole, a commonly used anti-fungal that inhibits Hedgehog pathway activity and cancer growth

In a screen of drugs previously tested in humans we identified itraconazole, a systemic antifungal, as a potent antagonist of the Hedgehog (Hh) signaling pathway that acts by a mechanism distinct from its inhibitory effect on fungal sterol biosynthesis. Systemically administered itraconazole, like o...

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Detalhes bibliográficos
Main Authors: Kim, James, Tang, Jean Y, Gong, Ruoyu, Kim, Jynho, Lee, John J., Clemons, Karl V., Chong, Curtis R., Chang, Kris S., Fereshteh, Mark, Reya, Tannishtha, Liu, Jun O., Epstein, Ervin H., Stevens, David A., Beachy, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039177/
https://ncbi.nlm.nih.gov/pubmed/20385363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.02.027
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