Itraconazole, a commonly used anti-fungal that inhibits Hedgehog pathway activity and cancer growth

In a screen of drugs previously tested in humans we identified itraconazole, a systemic antifungal, as a potent antagonist of the Hedgehog (Hh) signaling pathway that acts by a mechanism distinct from its inhibitory effect on fungal sterol biosynthesis. Systemically administered itraconazole, like o...

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Bibliografiset tiedot
Päätekijät: Kim, James, Tang, Jean Y, Gong, Ruoyu, Kim, Jynho, Lee, John J., Clemons, Karl V., Chong, Curtis R., Chang, Kris S., Fereshteh, Mark, Reya, Tannishtha, Liu, Jun O., Epstein, Ervin H., Stevens, David A., Beachy, Philip A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039177/
https://ncbi.nlm.nih.gov/pubmed/20385363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.02.027
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