Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists

Recognition of the multiple roles of Hedgehog signaling in cancer has prompted intensive efforts to develop targeted pathway inhibitors. Leading inhibitors in clinical development act by binding to a common site within Smoothened, a critical pathway component. Acquired Smoothened mutations, includin...

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Main Authors: Kim, James, Aftab, Blake T., Tang, Jean Y., Kim, Daniel, Lee, Alex H., Rezaee, Melika, Kim, Jynho, Chen, Baozhi, King, Emily M., Borodovsky, Alexandra, Riggins, Gregory J., Epstein, Ervin H., Beachy, Philip A., Rudin, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548977/
https://ncbi.nlm.nih.gov/pubmed/23291299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.11.017
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