Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists

Recognition of the multiple roles of Hedgehog signaling in cancer has prompted intensive efforts to develop targeted pathway inhibitors. Leading inhibitors in clinical development act by binding to a common site within Smoothened, a critical pathway component. Acquired Smoothened mutations, includin...

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Bibliografiske detaljer
Main Authors: Kim, James, Aftab, Blake T., Tang, Jean Y., Kim, Daniel, Lee, Alex H., Rezaee, Melika, Kim, Jynho, Chen, Baozhi, King, Emily M., Borodovsky, Alexandra, Riggins, Gregory J., Epstein, Ervin H., Beachy, Philip A., Rudin, Charles M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548977/
https://ncbi.nlm.nih.gov/pubmed/23291299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.11.017
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