Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists

Recognition of the multiple roles of Hedgehog signaling in cancer has prompted intensive efforts to develop targeted pathway inhibitors. Leading inhibitors in clinical development act by binding to a common site within Smoothened, a critical pathway component. Acquired Smoothened mutations, includin...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Kim, James, Aftab, Blake T., Tang, Jean Y., Kim, Daniel, Lee, Alex H., Rezaee, Melika, Kim, Jynho, Chen, Baozhi, King, Emily M., Borodovsky, Alexandra, Riggins, Gregory J., Epstein, Ervin H., Beachy, Philip A., Rudin, Charles M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548977/
https://ncbi.nlm.nih.gov/pubmed/23291299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.11.017
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы