Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma

IMPORTANCE: Tumor resistance is an emerging problem for Smoothened (SMO) inhibitor–treated metastatic basal cell carcinoma (BCC). Arsenic trioxide and itraconazole antagonize the hedgehog (HH) pathway at sites distinct from those treated by SMO inhibitors. OBJECTIVE: To determine whether administrat...

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Detalhes bibliográficos
Publicado no:JAMA Dermatol
Main Authors: Ally, Mina S., Ransohoff, Katherine, Sarin, Kavita, Atwood, Scott X., Rezaee, Melika, Bailey-Healy, Irene, Kim, Jynho, Beachy, Philip A., Chang, Anne Lynn S., Oro, Anthony, Tang, Jean Y., Colevas, A. Dimitrios
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833646/
https://ncbi.nlm.nih.gov/pubmed/26765315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamadermatol.2015.5473
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