Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma

IMPORTANCE: Tumor resistance is an emerging problem for Smoothened (SMO) inhibitor–treated metastatic basal cell carcinoma (BCC). Arsenic trioxide and itraconazole antagonize the hedgehog (HH) pathway at sites distinct from those treated by SMO inhibitors. OBJECTIVE: To determine whether administrat...

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Udgivet i:JAMA Dermatol
Main Authors: Ally, Mina S., Ransohoff, Katherine, Sarin, Kavita, Atwood, Scott X., Rezaee, Melika, Bailey-Healy, Irene, Kim, Jynho, Beachy, Philip A., Chang, Anne Lynn S., Oro, Anthony, Tang, Jean Y., Colevas, A. Dimitrios
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833646/
https://ncbi.nlm.nih.gov/pubmed/26765315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamadermatol.2015.5473
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