Smoothened variants explain the majority of drug resistance in basal cell carcinoma

Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms. Here, we identify SMO mutations in 50% (22/44) of resistant BCCs and show that these mutations maintain Hedgehog signaling in the presence of SMO inhibitors. Alterations inc...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Atwood, Scott X., Sarin, Kavita Y., Whitson, Ramon J., Li, Jiang R., Kim, Geurim, Rezaee, Melika, Ally, Mina S., Kim, Jinah, Yao, Catherine, Chang, Anne Lynn S., Oro, Anthony E., Tang, Jean Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357167/
https://ncbi.nlm.nih.gov/pubmed/25759020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.02.002
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