SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells

SIRT1 operates as both a tumor suppressor and oncogenic factor depending on the cell context. Whether SIRT1 plays a role in melanoma biology remained poorly elucidated. Here, we demonstrate that SIRT1 is a critical regulator of melanoma cell proliferation. SIRT1 suppression by genetic or pharmacolog...

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Hlavní autoři: Ohanna, Mickaël, Bonet, Caroline, Bille, Karine, Allegra, Maryline, Davidson, Irwin, Bahadoran, Philippe, Lacour, Jean-Philippe, Ballotti, Robert, Bertolotto, Corine
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039147/
https://ncbi.nlm.nih.gov/pubmed/24742694
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