Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype

In BRAF(V600E) melanoma cells, a global metabolomic analysis discloses a decrease in nicotinamide adenine dinucleotide (NAD(+)) levels upon PLX4032 treatment that is conveyed by a STAT5 inhibition and a transcriptional regulation of the nicotinamide phosphoribosyltransferase (NAMPT) gene. NAMPT inhi...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Ohanna, Mickaël, Cerezo, Mickaël, Nottet, Nicolas, Bille, Karine, Didier, Robin, Beranger, Guillaume, Mograbi, Baharia, Rocchi, Stéphane, Yvan-Charvet, Laurent, Ballotti, Robert, Bertolotto, Corine
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900716/
https://ncbi.nlm.nih.gov/pubmed/29567766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.305854.117
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