Aurora B Is Regulated by the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (MAPK/ERK) Signaling Pathway and Is a Valuable Potential Target in Melanoma Cells

Metastatic melanoma is a deadly skin cancer and is resistant to almost all existing treatment. Vemurafenib, which targets the BRAFV600E mutation, is one of the drugs that improves patient outcome, but the patients next develop secondary resistance and a return to cancer. Thus, new therapeutic strate...

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Bibliografiske detaljer
Main Authors: Bonet, Caroline, Giuliano, Sandy, Ohanna, Mickaël, Bille, Karine, Allegra, Maryline, Lacour, Jean-Philippe, Bahadoran, Philippe, Rocchi, Stéphane, Ballotti, Robert, Bertolotto, Corine
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436153/
https://ncbi.nlm.nih.gov/pubmed/22767597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371682
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