The Ah Receptor Recruits IKKα to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation

Aryl hydrocarbon receptor (AHR) activation by xenobiotic ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is key to their toxicity. Following activation and nuclear translocation, AHR heterodimerizes with the AHR nuclear translocator (ARNT) and binds to AHR response elements (AhREs) in the...

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Main Authors: Kurita, Hisaka, Schnekenburger, Michael, Ovesen, Jerald L., Xia, Ying, Puga, Alvaro
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Molecular Toxicology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038787/
https://ncbi.nlm.nih.gov/pubmed/24519526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu027
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