ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism

Epithelial tumor cells that have undergone epithelial-to-mesenchymal transition (EMT) are typically prone to metastasis and drug resistance and contribute to a poor clinical outcome. The transcription factor ZEB1 is a known driver of EMT, and mediators of ZEB1 represent potential therapeutic targets...

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Main Authors: Yang, Yanan, Ahn, Young-Ho, Chen, Yulong, Tan, Xiaochao, Guo, Lixia, Gibbons, Don L., Ungewiss, Christin, Peng, David H., Liu, Xin, Lin, Steven H., Thilaganathan, Nishan, Wistuba, Ignacio I., Rodriguez-Canales, Jaime, McLendon, Georgia, Creighton, Chad J., Kurie, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038569/
https://ncbi.nlm.nih.gov/pubmed/24762440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72171
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