A genetic cell context-dependent role for ZEB1 in lung cancer

The Zinc-finger E-box-binding Homeobox-1 (ZEB1) is a transcription factor that promotes epithelial–mesenchymal transition (EMT) and acts as an oncogene in KRAS-mutated lung cancer models. Here we report that ZEB1 exerts the opposite effect in EGFR-mutated lung cancer cells, where it suppresses growt...

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Vydáno v:Nat Commun
Hlavní autoři: Zhang, Ting, Guo, Lixia, Creighton, Chad J., Lu, Qiang, Gibbons, Don L., Yi, Eunhee S., Deng, Bo, Molina, Julian R., Sun, Zhifu, Yang, Ping, Yang, Yanan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963474/
https://ncbi.nlm.nih.gov/pubmed/27456471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12231
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