MHC-derived allopeptide activates TCR-biased CD8(+) Tregs and suppresses organ rejection

In a rat heart allograft model, preventing T cell costimulation with CD40Ig leads to indefinite allograft survival, which is mediated by the induction of CD8(+)CD45RC(lo) regulatory T cells (CD8(+)CD40Ig Tregs) interacting with plasmacytoid dendritic cells (pDCs). The role of TCR-MHC-peptide interac...

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Detalhes bibliográficos
Main Authors: Picarda, Elodie, Bézie, Séverine, Venturi, Vanessa, Echasserieau, Klara, Mérieau, Emmanuel, Delhumeau, Aurélie, Renaudin, Karine, Brouard, Sophie, Bernardeau, Karine, Anegon, Ignacio, Guillonneau, Carole
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038566/
https://ncbi.nlm.nih.gov/pubmed/24789907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71533
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