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MHC-derived allopeptide activates TCR-biased CD8(+) Tregs and suppresses organ rejection
In a rat heart allograft model, preventing T cell costimulation with CD40Ig leads to indefinite allograft survival, which is mediated by the induction of CD8(+)CD45RC(lo) regulatory T cells (CD8(+)CD40Ig Tregs) interacting with plasmacytoid dendritic cells (pDCs). The role of TCR-MHC-peptide interac...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2014
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4038566/ https://ncbi.nlm.nih.gov/pubmed/24789907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71533 |
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