SIRT1 Mediates FOXA2 Breakdown by Deacetylation in a Nutrient-Dependent Manner

The Forkhead transcription factor FOXA2 plays a fundamental role in controlling metabolic homeostasis in the liver during fasting. The precise molecular regulation of FOXA2 in response to nutrients is not fully understood. Here, we studied whether FOXA2 could be controlled at a post-translational le...

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Detalhes bibliográficos
Main Authors: van Gent, Rogier, Di Sanza, Claudio, van den Broek, Niels J. F., Fleskens, Veerle, Veenstra, Aukje, Stout, Gerdine J., Brenkman, Arjan B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038515/
https://ncbi.nlm.nih.gov/pubmed/24875183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098438
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