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Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
The activity of Rb (retinoblastoma protein) is regulated by phosphorylation and acetylation events. Active Rb is hypophosphorylated and acetylated on multiple residues. Inactivation of Rb involves concerted hyper-phosphorylation by cyclin–CDK (cyclin-dependent kinase) complexes combined with deacety...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Portland Press Ltd.
2007
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275065/ https://ncbi.nlm.nih.gov/pubmed/17620057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070151 |
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