Loading...

SIRT1: Regulator of p53 Deacetylation

The cellular NAD(+)/NADH level controls Sir2 (silent information regulator 2) deacetylase activity in regulating aging in lower species. Much work has been put forth to identify ways to activate SIRT1, the mammalian ortholog of Sir2. The identification of p53 as a bona fide substrate of SIRT1 deacet...

Full description

Saved in:
Bibliographic Details
Main Authors: Lee, James T., Gu, Wei
Format: Artigo
Language:Inglês
Published: SAGE Publications 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764473/
https://ncbi.nlm.nih.gov/pubmed/24020002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601913484496
Tags: Add Tag
No Tags, Be the first to tag this record!