SIRT1 Mediates FOXA2 Breakdown by Deacetylation in a Nutrient-Dependent Manner

The Forkhead transcription factor FOXA2 plays a fundamental role in controlling metabolic homeostasis in the liver during fasting. The precise molecular regulation of FOXA2 in response to nutrients is not fully understood. Here, we studied whether FOXA2 could be controlled at a post-translational le...

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Autors principals: van Gent, Rogier, Di Sanza, Claudio, van den Broek, Niels J. F., Fleskens, Veerle, Veenstra, Aukje, Stout, Gerdine J., Brenkman, Arjan B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038515/
https://ncbi.nlm.nih.gov/pubmed/24875183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098438
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