SIRT1 Mediates FOXA2 Breakdown by Deacetylation in a Nutrient-Dependent Manner

The Forkhead transcription factor FOXA2 plays a fundamental role in controlling metabolic homeostasis in the liver during fasting. The precise molecular regulation of FOXA2 in response to nutrients is not fully understood. Here, we studied whether FOXA2 could be controlled at a post-translational le...

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Библиографические подробности
Главные авторы: van Gent, Rogier, Di Sanza, Claudio, van den Broek, Niels J. F., Fleskens, Veerle, Veenstra, Aukje, Stout, Gerdine J., Brenkman, Arjan B.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2014
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038515/
https://ncbi.nlm.nih.gov/pubmed/24875183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098438
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