The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis

Female A/J mice injected with the carcinogen vinyl carbamate develop atypical adenomatous hyperplasias in lungs 4 weeks after injection with the carcinogen. The number and severity of tumors then increase over time, making these mice a useful model for evaluating potential chemopreventive agents. Th...

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Main Authors: Liby, Karen, Black, Candice C., Royce, Darlene B., Williams, Charlotte R., Risingsong, Renee, Yore, Mark M., Liu, Xi, Honda, Tadashi, Gribble, Gordon W., Lamph, William W., Sporn, Thomas A., Dmitrovsky, Ethan, Sporn, Michael B.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036619/
https://ncbi.nlm.nih.gov/pubmed/18483313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0023
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