Role of c-Met/Phosphatidylinositol 3-Kinase (PI3k)/Akt Signaling in Hepatocyte Growth Factor (HGF)-mediated Lamellipodia Formation, Reactive Oxygen Species (ROS) Generation, and Motility of Lung Endothelial Cells

Hepatocyte growth factor (HGF) mediated signaling promotes cell proliferation and migration in a variety of cell types and plays a key role in tumorigenesis. As cell migration is important to angiogenesis, we characterized HGF-mediated effects on the formation of lamellipodia, a pre-requisite for mi...

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Bibliografiska uppgifter
Huvudupphovsmän: Usatyuk, Peter V., Fu, Panfeng, Mohan, Vijay, Epshtein, Yulia, Jacobson, Jeffrey R., Gomez-Cambronero, Julian, Wary, Kishore K., Bindokas, Vytas, Dudek, Steven M., Salgia, Ravi, Garcia, Joe G. N., Natarajan, Viswanathan
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036355/
https://ncbi.nlm.nih.gov/pubmed/24634221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527556
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