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Binding Site and Inhibitory Mechanism of the Mambalgin-2 Pain-relieving Peptide on Acid-sensing Ion Channel 1a

Acid-sensing ion channels (ASICs) are neuronal proton-gated cation channels associated with nociception, fear, depression, seizure, and neuronal degeneration, suggesting roles in pain and neurological and psychiatric disorders. We have recently discovered black mamba venom peptides called mambalgin-...

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Bibliografiske detaljer
Main Authors: Salinas, Miguel, Besson, Thomas, Delettre, Quentin, Diochot, Sylvie, Boulakirba, Sonia, Douguet, Dominique, Lingueglia, Eric
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036345/
https://ncbi.nlm.nih.gov/pubmed/24695733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.561076
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