Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition

Mambalgins are peptides isolated from mamba venom that specifically inhibit a set of acid-sensing ion channels (ASICs) to relieve pain. We show here the first full stepwise solid phase peptide synthesis of mambalgin-1 and confirm the biological activity of the synthetic toxin both in vitro and in vi...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Mourier, Gilles, Salinas, Miguel, Kessler, Pascal, Stura, Enrico A., Leblanc, Mathieu, Tepshi, Livia, Besson, Thomas, Diochot, Sylvie, Baron, Anne, Douguet, Dominique, Lingueglia, Eric, Servent, Denis
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2016
Konular:
Neurobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742732/
https://ncbi.nlm.nih.gov/pubmed/26680001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.702373
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