Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition

Mambalgins are peptides isolated from mamba venom that specifically inhibit a set of acid-sensing ion channels (ASICs) to relieve pain. We show here the first full stepwise solid phase peptide synthesis of mambalgin-1 and confirm the biological activity of the synthetic toxin both in vitro and in vi...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Mourier, Gilles, Salinas, Miguel, Kessler, Pascal, Stura, Enrico A., Leblanc, Mathieu, Tepshi, Livia, Besson, Thomas, Diochot, Sylvie, Baron, Anne, Douguet, Dominique, Lingueglia, Eric, Servent, Denis
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2016
Предметы:
Neurobiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742732/
https://ncbi.nlm.nih.gov/pubmed/26680001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.702373
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы