Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect

Acid-sensing ion channels (ASICs) are neuronal voltage-independent Na(+) channels that are activated by extracellular acidification. ASICs play essential roles in a wide range of physiological processes, including sodium homeostasis, synaptic plasticity, neurodegeneration, and sensory transduction....

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Pubblicato in:Cell Discov
Autori principali: Sun, Demeng, Yu, You, Xue, Xiaobin, Pan, Man, Wen, Ming, Li, Siyu, Qu, Qian, Li, Xiaorun, Zhang, Longhua, Li, Xueming, Liu, Lei, Yang, Maojun, Tian, Changlin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986765/
https://ncbi.nlm.nih.gov/pubmed/29872539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-018-0026-1
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