Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1

Acid-sensing ion channels (ASICs) are proton-gated cation channels that are involved in diverse neuronal processes including pain sensing. The peptide toxin Mambalgin1 (Mamba1) from black mamba snake venom can reversibly inhibit the conductance of ASICs, causing an analgesic effect. However, the det...

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Udgivet i:eLife
Main Authors: Sun, Demeng, Liu, Sanling, Li, Siyu, Zhang, Mengge, Yang, Fan, Wen, Ming, Shi, Pan, Wang, Tao, Pan, Man, Chang, Shenghai, Zhang, Xing, Zhang, Longhua, Tian, Changlin, Liu, Lei
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Structural Biology and Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553779/
https://ncbi.nlm.nih.gov/pubmed/32915133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57096
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