Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1

Acid-sensing ion channels (ASICs) are proton-gated cation channels that are involved in diverse neuronal processes including pain sensing. The peptide toxin Mambalgin1 (Mamba1) from black mamba snake venom can reversibly inhibit the conductance of ASICs, causing an analgesic effect. However, the det...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Sun, Demeng, Liu, Sanling, Li, Siyu, Zhang, Mengge, Yang, Fan, Wen, Ming, Shi, Pan, Wang, Tao, Pan, Man, Chang, Shenghai, Zhang, Xing, Zhang, Longhua, Tian, Changlin, Liu, Lei
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2020
Ämnen:
Structural Biology and Molecular Biophysics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553779/
https://ncbi.nlm.nih.gov/pubmed/32915133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57096
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