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Cross-talk between Sirtuin and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in the Regulation of S6 Kinase 1 (S6K1) Phosphorylation

p70 ribosomal S6 kinase (S6K1), a major substrate of the mammalian target of rapamycin (mTOR) kinase, regulates diverse cellular processes including protein synthesis, cell growth, and survival. Although it is well known that the activity of S6K1 is tightly coupled to its phosphorylation status, the...

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Bibliografski detalji
Glavni autori: Hong, Sungki, Zhao, Bin, Lombard, David B., Fingar, Diane C., Inoki, Ken
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036325/
https://ncbi.nlm.nih.gov/pubmed/24652283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520734
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