NADH Binds and Stabilizes the 26S Proteasomes Independent of ATP

The 26S proteasome is the end point of the ubiquitin- and ATP-dependent degradation pathway. The 26S proteasome complex (26S PC) integrity and function has been shown to be highly dependent on ATP and its homolog nucleotides. We report here that the redox molecule NADH binds the 26S PC and is suffic...

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Bibliographic Details
Main Authors: Tsvetkov, Peter, Myers, Nadav, Eliav, Raz, Adamovich, Yaarit, Hagai, Tzachi, Adler, Julia, Navon, Ami, Shaul, Yosef
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036265/
https://ncbi.nlm.nih.gov/pubmed/24596095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.537175
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