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NADH Binds and Stabilizes the 26S Proteasomes Independent of ATP

The 26S proteasome is the end point of the ubiquitin- and ATP-dependent degradation pathway. The 26S proteasome complex (26S PC) integrity and function has been shown to be highly dependent on ATP and its homolog nucleotides. We report here that the redox molecule NADH binds the 26S PC and is suffic...

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Detalhes bibliográficos
Main Authors: Tsvetkov, Peter, Myers, Nadav, Eliav, Raz, Adamovich, Yaarit, Hagai, Tzachi, Adler, Julia, Navon, Ami, Shaul, Yosef
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036265/
https://ncbi.nlm.nih.gov/pubmed/24596095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.537175
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