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Biophysical Underpinnings of the Repeat Length Dependence of Polyglutamine Amyloid Formation
There are now 10 expanded CAG repeat diseases in which both disease risk and age of onset are strongly dependent on the repeat length of the polyglutamine (polyQ) sequence in the disease protein. Large, polyQ-rich inclusions in patient brains and in cell and animal models are consistent with the inv...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4036150/ https://ncbi.nlm.nih.gov/pubmed/24596088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C114.552943 |
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